Cerebral oxygenation and haemodynamic effectsinduced by nimodipine in healthy subjects

Canova, Daniele and Roatta, Silvestro and Micieli, Giuseppe and Bosone, Daniele (2012) Cerebral oxygenation and haemodynamic effectsinduced by nimodipine in healthy subjects. Functional Neurology : New Trends in Interventional Neurosciences, XXVII (3). pp. 169-176. ISSN 0393-5264

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Abstract

The cerebrovascular effects of nimodipine are stillpoorly understood even in the healthy condition; in par-ticular, its effects on tissue oxygenation have neverbeen investigated. The aim of the present study was to investigatechanges in cerebral oxygenation and blood volume up-on oral administration of nimodipine (90 mg) in thehealthy condition. In eight subjects, changes in cerebral tissue oxygena-tion and blood volume were determined simultaneous-ly with changes in blood velocity of the middle cerebralartery (VMCA) by using, respectively, near infrared spec-troscopy (NIRS) and transcranial Doppler ultrasonogra-phy (TCD). The subjects also underwent non-invasiveassessment of arterial blood pressure (ABP) and end-tidal CO2. TCD and NIRS CO2reactivity indices were al-so extracted. Nimodipine significantly reduced ABP (11±13%) and in-creased heart rate, as well as NIRS oxygenation(6.0±4.8%) and blood volume indices (9.4±10.1%), whileVMCAwas not significantly decreased (2.0±3.5%). Ni-modipine slightly but significantly reduced the VMCAre-sponse to changes in pCO2whereas the CO2reactivityof NIRS parameters was improved. The observed changes in cerebral tissue oxygenationand blood volume indicate nimodipine-induced cere-brovascular dilation and increased perfusion, while theeffect on VMCApossibly results from dilation of the in-sonated artery. The present results cast doubt on theputative nimodipine-induced impairment of CO2reac-tivity.

Item Type:	Article
Uncontrolled Keywords:	Physical therapy program for cervical dystonia:a study of 20 cases
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User:	Chiara Bisogno
Date Deposited:	10 Sep 2019 12:58
Last Modified:	10 Sep 2019 14:45
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5258

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