Antenatally diagnosed congenital cystic adenomatoid malformations (CCAM): Research Review

Di Prima, Fosca Antonia Francesca and Bellia, Adriana and Inclimona, Genny and Grasso, Francesco and Meli, Maria Teresa and Cassaro, Nazario (2012) Antenatally diagnosed congenital cystic adenomatoid malformations (CCAM): Research Review. Journal of prenatal medicine, 6 (2). pp. 22-30. ISSN 1971-3290

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Abstract

Prenatal identification of lung abnormalities has increased with prenatal surveillance. With the advent of improved antenatal imaging over the past ten years, the diagnosis, assessment and management of congenital cystic lung abnormalities have changed. These were once considered the exclusive domain of the surgeon, who had the authority to operate on all congenital cystic lung abnormalities regardless of size or clinical signs in order to avoid the risk of cancer and improve lung growth in even asymptomatic infants. Clinicians are reconsidering this approach in the light of the spontaneous improvement and possible resolution that occurs over months to years with many of these lesions, thinking about the opportunity to take a more conservative approach in many minimally symptomatic or asymptomatic infants in the early months of life. The risks of subsequent cancer are poorly understood and probably overstated. Many centers advocate surgery only in cases of symptomatic or significant lesions, although there is little consensus as to what constitutes a significant lesion. This article will review current knowledge (classification, pathogenesis, genetics, prenatal evaluation, clinical implications) on congenital cystic adenomatoid malformations (CCAM) and discuss management options for young children with these lung abnormalities.

Item Type:	Article
Uncontrolled Keywords:	Fetal lung, CCAM, cystic adenomatoid malformations
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria > 618.3 Malattie e complicazioni della gravidanza
Depositing User:	Gianni Aiello
Date Deposited:	29 May 2013 10:51
Last Modified:	29 May 2013 10:51
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5367

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