Carbetocin versus oxytocin in caesarean section with high risk of post-partum haemorrhage

Larciprete, Giovanni and Montagnoli, Carlotta and Frigo, Maria Grazia and Panetta, Valentina and Todde, Cristina and Zuppani, Benedetta and Centonze, Chiara and Bompiani, Alessandro and Melandrenis, Ioannis and Cirese, Alio and Valensise, Herbert (2013) Carbetocin versus oxytocin in caesarean section with high risk of post-partum haemorrhage. Journal of prenatal medicine, 7 (1). pp. 12-18. ISSN 1971-3290

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Objectives: the aims of the present study were to compare the haemodynamic effects of oxytocin and carbetocin and to assess the efficacy of these two drugs in terms of blood loss and the additional uterotonic needed in caesarean section at high risk of primary post-partum haemorrhage. Methods: women in the carbetocin group (group A) received a bolus of 100 μg IV; women in the control group (group B) received 20 IU of oxytocin in 1000 ml of 0,9% Na- Cl solution IV (150 mL/ hour). The main parameter evaluated was the haemodynamic effects of drugs and the need for additional uterotonic agents. In addition we compared the drop in haemoglobin level, the uterine tone, the uterine fundal state and the diuresis. Results: regarding the haemodynamic effects, both drugs have a hypotensive effect, but we found a greater reduction in blood pressure within the oxytocin group. Significantly more women needed additional uterotonic agents in the oxytocin group (23,5% vs 0%, p<0.01), though there was no significant difference in estimated blood loss and in the drop haemoglobin level (p>0.05). There was a significant difference in the diuresis, higher in carbetocin group (1300 ml ± 450 ml vs 1100 ml ± 250 ml, p=0.01). Conclusions: a single injection of carbetocin appears to be more effective than a continuous infusion of oxytocin to prevent the PPH, with a similar haemodynamic profile and minor antidiuretic effect.

Item Type: Article
Uncontrolled Keywords: Post-partum haemorrhage, uterotonic drugs, carbetocin, oxytocin
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 618 Altri rami della medicina; Ginecologia e ostetricia, Pediatria, Geriatria > 618.2 Ostetricia
Depositing User: Gianni Aiello
Date Deposited: 29 May 2013 13:17
Last Modified: 10 Apr 2014 13:05

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