White matter microstructure alterations in bipolar disorder

Bellani, Marcella and Perlini, Cinzia and Ferro, Adele and Cerruti, Stefania and Rambaldelli, Gianluca and Isola, Miriam and Cerini, Roberto and Dusi, Nicola and Andreone, Nicola and Balestrieri, Matteo (2012) White matter microstructure alterations in bipolar disorder. New Trends in interventional neurosciences, 27 (1). pp. 29-34. ISSN 0393-5264

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Genetic, neuropathological and magnetic resonance imaging findings support the presence of diffuse white matter cytoarchitectural disruption in bipolar disorder. In this study, diffusion-weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 patients with DSM-IV bipolar disorder and 35 matched normal controls. DWI images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined over regions of interest placed, bilaterally, in the frontal, temporal, parietal, and occipital white matter. Significantly increased ADC values were found in bipolar patients with respect to normal controls in the right temporal lobe, left parietal lobe and bilateral occipital lobes. ADC values did not associate significantly with age or with clinical variables (p>0.05). Diffuse cortical white matter alterations on DWI in bipolar disorder denote widespread disruption of white matter integrity and may be due to altered myelination and/or axonal integrity.

Item Type: Article
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.8 Malattie del sistema nervoso e disturbi mentali (Classificare qui la Neuropsichiatria, la Neurologia)
Depositing User: Chiara Bisogno
Date Deposited: 10 Sep 2019 14:25
Last Modified: 10 Sep 2019 14:25
URI: http://eprints.bice.rm.cnr.it/id/eprint/5610

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