Radioterapia intraoperatoria (IORT) nel carcinoma mammario in stadio iniziale. Risultati preliminari in 77 pazienti

Valduga, Paolo and Zani, B. and Mussari, Salvatore and Eccher, C. (2009) Radioterapia intraoperatoria (IORT) nel carcinoma mammario in stadio iniziale. Risultati preliminari in 77 pazienti. Il giornale di chirurgia, 30 (5 Supp). pp. 26-27. ISSN 1971-145X

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Purpose: To verify feasibility and effectiveness of IORT (intraoperative radiotherapy) in patients with early stage breast cancer, especially in regard to prevention of recurrence and treatment toxicity. Methods: From october 2000 to november 2006 we operated on 77 patients with stage I breast cancer. We have selected these patients on the basis of a preestablished experimental IORT protocol, participing in a national research project. All these patients underwent a surgical procedure including quadrantectomy of the breast and IORT (average dose 23 Gy). Results: The median follow-up is 69 months (range 18-94 months). We didn’t detected local relapses in any patient. One patients developed further cancer in the other breast. Two patients developed metastasis (one dead). The wound-healing average time was 8 days. We evalueted the treatment late toxicity at 36 months in 64 patients: we detected circumscribed fibrosis (grade 2) in 19 patients; fibrosis with skin retraction (grade 3) in 2 patients; symptomless fat-necrosis in 39 patients (mammographic finding). Conclusions: In our experience, concerning conservative treatment of early breast cancer, IORT proved to be a feasible procedure, causing poor morbidity. However, in spite of valuable preliminary results, a longer follow-up is required to establish the impact of IORT on relapse control and final cosmetic result.

Item Type: Article
Uncontrolled Keywords: Intraoperative radiotherapy, IORT, breast cancer
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User: Nadia Del Gobbo
Date Deposited: 08 Feb 2016 15:41
Last Modified: 08 Feb 2016 16:37

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