La sede anatomica come fattore prognostico nei tumori gastrointestinali stromali (GIST): nostra esperienza

Montemurro, Severino and Caliandro, Cosimo and Cartanese, Carmine and De Luca, R. and Ruggieri, E. and Rucci, A. and Sciscio, Vito (2009) La sede anatomica come fattore prognostico nei tumori gastrointestinali stromali (GIST): nostra esperienza. Il giornale di chirurgia, 30 (5 Supp). p. 95. ISSN 1971-145X

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Abstract

GISTs are the most common mesenchimal tumors and represent approximately 1% of all of the gastrointestinal tract cancers. The treatment for localized GISTs is the surgical excision with macroscopically negative margins. However, recurrence is a relatively common event even after a complete resection. Almost 30% of recurrences are locally and distant metastases represent the 50% of total recurrences. Materials and methods: From July 2002 to March 2009 a total of nineteen patients (12 males, 7 females), median age 65 years (49-79),underwent curative resection (R0). Tumor site: stomach 12; small intestine 5; colon rectum 2. Surgical treatments: segmental resection of small intestine (5); gastric wedge resection (9), subtotal gastrectomy (2); gastric resection extended to distal splenopancreasectomy (1); right colectomy (1); anterior resection (1). Results: Gastric GISTs were high grade in 4 patients, intermediate in 1 patient and low-risk in 7 patients. Small intestine GISTs were high grade in 2, intermediate in 2 and low in 1 patient, respectively. Colorectal GISTs were high in 1 and intermediate in 1 patient, respectively. Lymphonodal metastases were found in one patient with high risk stomach GIST. After a median follow up of 40 months, 15 patients are alive and free disease; 4 male patient (1 high risk stomach, 1 intermediate and I low risk small intestine, 1 high risk rectum) have a recurrence, two local (pelvis) and 2 distant (liver), respectively. The rate of relapse is 8% in stomach, 40% in small intestine and 50% in rectum. Discussion: Several studies have shown that different anatomical locations of GISTs have different clinical, histological, immunohistochemical and genetic characteristics, suggesting that the anatomical location could be a prognostic factor independent of tumor size and mitotic rate. Our experience confirms data from the literature. .

Item Type:	Article
Uncontrolled Keywords:	Tumori stromali gastrointestinali, sede, prognosi
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	09 Feb 2016 17:05
Last Modified:	09 Feb 2016 17:05
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5879

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