Bone healing: little secrets

Einhorn, Thomas A. (2011) Bone healing: little secrets. Clinical cases in mineral and bone metabolism, 8 (1). pp. 17-20. ISSN 1971-3266

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The development of new strategies to enhance the healing of fractures continues to evolve with the introduction of both locally and systemically delivered compounds. The recent refinement in the use of autologous bone marrow as a bone graft material has brought the field of stem cell biology into orthopaedic practice. New recombinant peptides such as platelet-derived growth factor and teriparatide show promise as local and systemic enhancers respectively. Finally, recent evidence that mutations in elements of the Wnt signaling pathway lead to gain-of-function mutations in bone formation in rare clinical settings has provided the basis for the targeting of this pathway for the development of therapeutic agents for bone repair. These recent developments are presented as the “little secrets” of present day bone healing

Item Type: Article
Uncontrolled Keywords: Platelet Derived Growth Factor; pathyroid hormone; bone marrow; Wnt signalling molecules
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 10 Jan 2014 12:09
Last Modified: 10 Jan 2014 12:09

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