The use of autologous blood-derived growth factors in bone regeneration

Civinini, Roberto and Macera, Armando and Nistri, Lorenzo and Redl, Birgit and Innocenti, Massimo (2011) The use of autologous blood-derived growth factors in bone regeneration. Clinical cases in mineral and bone metabolism, 8 (1). pp. 25-31. ISSN 1971-3266

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Platelet-rich plasma (PRP) is defined as a portion of the plasma fraction of autologous blood having platelet concentrations above baseline. When activated the platelets release growth factors that play an essential role in bone healing such as Platelet-derived Growth Factor, Transforming Growth Factor-β, Vascular Endothelial Growth Factor and others. Multiple basic science and in vivo animal studies agree that PRP has a role in the stimulation of the healing cascade in ligament, tendon, muscle cartilage and in bone regeneration in the last years PRP had a widespread diffusion in the treatment of soft tissue and bone healing. The purpose of this review is to describe the biological properties of platelets and its factors, the methods used for producing PRP, to provide a background on the underlying basic science and an overview of evidence based medicine on clinical application of PRP in bone healing

Item Type: Article
Uncontrolled Keywords: Growth factors; bone regeneration; Platelet-Rich Plasma
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 10 Jan 2014 11:54
Last Modified: 10 Jan 2014 11:54

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