Bone disease in HIV infection

Saccomanno, Maristella Francesca and Ammassari, Adriana (2011) Bone disease in HIV infection. Clinical cases in mineral and bone metabolism, 8 (1). pp. 33-36. ISSN 1971-3266

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Abstract

he advent of highly active anti-retroviral therapy (HAART) has dramatically decreased the rate of AIDS-related mortality and significantly extended the life span of patients with AIDS. A variety of metabolic side effects are associated with these therapies, one of which is metabolic bone disease. The causes of low bone mineral density (BMD) in individuals with HIV infection appear to be multifactorial and likely represent a complex interaction between HIV infection, traditional osteoporosis risk factors, and antiretroviral related factors. This review summarizes the clinical evidence linking HIVassociated osteoporosis to direct infection and antiretroviral therapy use. The purported mechanisms involved in bone loss are also reviewed. Additionally, recommendations regarding the pharmacologic management of HIV/HAART-related osteoporosis are given. In conclusion, we make the point that HIV infection should be considered as a risk factor for bone disease

Item Type:	Article
Uncontrolled Keywords:	HIV, antiretroviral therapy, osteopenia/osteoporosis, bone density
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	10 Jan 2014 11:52
Last Modified:	10 Jan 2014 11:52
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5962

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