Ibandronate and periprosthetic bone mass: new therapeutic approach in periprosthetic loosening prevention

Muratore, Maurizio and Quarta, Eugenio and Quarta, Laura and Grimaldi, Antonella and Orgiani, Antonio and Marsilio, Antonio and Rollo, Giuseppe (2011) Ibandronate and periprosthetic bone mass: new therapeutic approach in periprosthetic loosening prevention. Clinical cases in mineral and bone metabolism, 8 (1). pp. 55-56. ISSN 1971-3266

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Abstract

A prosthetic implant modifies the physiological transmission of loads to the bone, initiating a remodeling process. Studies of the mechanisms responsible for periprosthetic bone loss contributed to the definition of new pharmacological strategies that may prevent aseptic implant loosening. Bisphosphonates are a class of drugs useful to this purpose, and have been shown to be effective in reducing periprosthetic resorption during the first year after the implant. We aimed to assess the inhibitory effect on periprosthetic osteolysis of ibandronate, a highly potent aminobisphosphonate, administered orally and IV with an extended interval between doses and optimal treatment adherence. In view of the fact that periprosthetic remodeling takes place during the first 6-12 months after surgery and is ultimately responsible for prosthesis longevity, we may conclude that the administration of high dosage ibandronate postsurgery by IV bolus and subsequently as cyclic oral treatment reduced cortical osteopenia in the metaphyseal region, and in the calcar region of the proximal femur. This therapy might therefore be used as preventive measure against postsurgical osteopenia and probably also against aseptic loosening

Item Type:	Article
Uncontrolled Keywords:	Periprosthetic bone loss, ibandronate, bisphosphonates
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	10 Jan 2014 11:40
Last Modified:	10 Jan 2014 11:40
URI:	http://eprints.bice.rm.cnr.it/id/eprint/5965

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