Compliance to antifracture treatments in Tuscany: a regional survey based on institutional pharmaceutical dataset

Piscitelli, Prisco and Marcucci, Gemma and Parri, Simone and Cavalli, Loredana and Pazzagli, Luciana and Batacchi, Paolo and Brocca, Teresa and Giovannini, Valtere and Brandi, Maria Luisa and Colli, Emanuela (2011) Compliance to antifracture treatments in Tuscany: a regional survey based on institutional pharmaceutical dataset. Clinical cases in mineral and bone metabolism, 8 (2). pp. 62-65. ISSN 1971-3266

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Objective: compliance to any antifracture therapy is the most important parameter affecting the effectiveness of the treatment. The aim of this study was to evaluate patients compliance to antifracture therapies in the whole Tuscany population who benefit from treatments reimbursed by the Regional Healthcare System. Methods: we have analyzed all antifracture drug prescriptions recorded in Tuscany regional pharmaceutical database concerning year 2009, from both in-hospital distribution database (direct drug delivery, FED), and private pharmacies across the whole region (SPF). Patients who started the treatment in 2008 and those continuing it in 2010 were also considered in the analysis. The sample size consisted in 92,250 people (1:9 male to female ratio). Compliance to antifracture treatments at 3, 6, 9, and 12 months was analyzed by single drug (using the defined daily dose, DDD), and by age group (40-50, 50-60, 60-70, 70-80, 90-100 years). Results: patients compliance decreased under 80% after the first 3 months of treatment, reaching no more than 50% at 1 year. Our results show that compliance to antifracture treatments reflects the age of the patients. People aged 70-80 years old represent the age group most frequently treated with antifracture therapies (36.57% of total prescriptions), with alendronic acid being the most prescribed drug (29.73% of total drug prescribed). Monthly dosing did not increase compliance if compared to oral weekly regimens, while daily oral or s.c. dosing were associated to lower compliance rates. Conclusion: serious efforts need to be implemented to foster patients motivation in assuming their antifracture treatments for at least one year

Item Type: Article
Uncontrolled Keywords: Antifracture drugs; compliance; efficacy; institutional database
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 08 Jan 2014 12:09
Last Modified: 08 Jan 2014 12:09

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