Tissue bioengineering in orthopedics

Hernigou, Philippe and Yasuhiro, Homma (2012) Tissue bioengineering in orthopedics. Clinical cases in mineral and bone metabolism, 9 (1). pp. 21-23. ISSN 1971-3266

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The use of cells for the purpose of orthopedic tissue engineering started more than 300 years ago. The first attempt of bone grafting was reported in 1668 by the Dutch surgeon Job-Van Meek'ren. In 1867, Ollier performed a series of experiments using transplanted periosteum and concluded that transplanted periosteum and bone remained alive and formed new bone. The osteogenic potential of transplanted bone marrow was later documented by Goujon in 1869, then by Macewen in 1881. Efforts of Albee and Phemister highlighted further the utility of bone transplantation for the healing of fractures and bone defects. The techniques for autografting pioneered by these individuals remained largely unchanged until today. Advances in understanding of the biology of osteogenic cells, the availability of many highly purified peptide growth factors, and the capacity to create highly specialized implantable materials have launched an explosion of new advances in bone grafting and bone regeneration, all under the banner of tissue engineering. This new field is rapidly expanding the armamentarium of orthopedic surgeons in every setting in which bone healing is required. Composites of cells and matrices are at the core of this revolution

Item Type: Article
Uncontrolled Keywords: Bone; stem cells; tissue engineering
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 08 Jan 2014 10:00
Last Modified: 08 Jan 2014 10:00
URI: http://eprints.bice.rm.cnr.it/id/eprint/6025

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