Calcium supplementation and risk of cardiovascular disease

Nuti, Ranuccio (2012) Calcium supplementation and risk of cardiovascular disease. Clinical cases in mineral and bone metabolism, 9 (3). pp. 133-134. ISSN 1971-3266

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With the outcome to demonstrate the efficacy of calcium to prevent the incidence of fractures many randomized controlled trials have been performed in the past two decades, with conflicting results. A RR of 0.86 for non-vertebral fractures and a RR of 0.91 for hip fractures on eight trials were demonstrated. Calcium supplementation is considered particularly important when baseline calcium intake is low. More recently WHI CaD Study indicated hat calcium supplements with or without vitamin D represent a factor risk for cardiovascular events. On the other hand the beneficial effect of a correct calcium intake in attaining and maintaining bone mass across the life is largely demonstrated. There is an urgent need for more research to gain insight into the mechanisms of the adverse vascular effect of calcium. Moreover, more extensive data about the incidence of cardiovascular adverse events coming from randomized controlled intervention trials in osteoporosis, in which calcium plus Vitamin D were utilized, might be achieved

Item Type: Article
Uncontrolled Keywords: Calcium; vitamin D; osteoporosis; fracture; prevention
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 03 Dec 2013 11:04
Last Modified: 03 Dec 2013 11:04

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