IL-18 gene promoter polymorphisms are only moderately associated with periodontal disease in Italian population

Martelli, Francesco Saverio and Mengoni , Alessio and Martelli, Maria Laura and Rosati, Claudio and Fanti , Elena (2012) IL-18 gene promoter polymorphisms are only moderately associated with periodontal disease in Italian population. Clinical cases in mineral and bone metabolism, 9 (3). pp. 153-156. ISSN 1971-3266

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Objective. The aim of this study was to determine the impact of the polymorphisms at position -607 (C/A) and -137 (G/C) in the promoter of the IL-18 gene and their haplotypes, on the individual susceptibility of developing Aggressive (AgP) and/or Chronic (CP) periodontitis. Materials and methods. A total of 213 unrelated Italian subjects with periodontitis (AgP=109 and CP=104) and 100 periodontal-health subjects were studied. IL-18 gene promoter polymorphisms were analyzed by TaqMan® SNP Genotyping Assays. Genotype and allele frequencies were analyzed using the chi-square test and multiple logistic regression analysis. Results. χ2 of comparisons between diseased patients and healthy controls indicated a significant differentiation between the control and AP and CP groups (χ2=26.359, P<0.02). Interestingly, genotypes AACG, AACC and AACG have a moderate association with AgP and CP. For alleles, multiple logistic regression analysis showed that the polymorphism CG at position -137 is moderately associated with AgP (ExpB=2.880), while the polymorphism AA at position-607 is moderately associated with CP (ExpB=2.076). Finally, a moderate association of CA at position -607 (ExpB=2.099) with the healthy status compared to aggressive periodontitis was found. Conclusions. Results obtained indicated the presence of some potential moderate protective and moderate susceptible alleles and genotypes to both aggressive and chronic periodontitis, demonstrating that IL-18 -607 C/A and -137 G/C gene promoter polymorphisms are not suitable diagnostic features for AgP and CP

Item Type: Article
Uncontrolled Keywords: Periodontitis; IL-18; inflammation
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 03 Dec 2013 09:59
Last Modified: 03 Dec 2013 09:59

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