Negri, Armando Luis and Spivacow, Francisco Rodolfo (2012) Healing of subtrochanteric atypical fractures after strontium ranelate treatment. Clinical cases in mineral and bone metabolism, 9 (3). pp. 166-169. ISSN 1971-3266
|
PDF
portiere.pdf - Published Version Download (991kB) |
Abstract
Oral bisphosphonates comprise the most widely prescribed class of antiosteoporotic drugs. Recent reports, however, suggest a link between prolonged bisphosphonate use and atypical low-energy, subtrochanteric fractures. We describe the clinical course of two patient treated for a long term with different bisphosphonates who developed subtrochanteric atypical fractures. They were treated initially with intramedullary rodding without pain disappearance or healing of the fracture. Strontium ranelate, a new orally administered agent for the treatment of osteoporosis, was given to these patients with complete closure of the fracture and pain disappearance after a few months. We conclude that based on the chronology of fracture healing and pain disappearance of our patients and published evidence that strontium ranelate can accelerate fracture healing in a rat model, that strontium ranelate had a positive anabolic effect that contributed to fracture healing that produced the secondary disappearance of pain
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Bisphosphonate, atypical fractures, delayed healing, strontium ranelate |
Subjects: | 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento |
Depositing User: | Danilo Dezzi |
Date Deposited: | 03 Dec 2013 09:49 |
Last Modified: | 03 Dec 2013 09:49 |
URI: | http://eprints.bice.rm.cnr.it/id/eprint/6086 |
Actions (login required)
View Item |