Healing of subtrochanteric atypical fractures after strontium ranelate treatment

Negri, Armando Luis and Spivacow, Francisco Rodolfo (2012) Healing of subtrochanteric atypical fractures after strontium ranelate treatment. Clinical cases in mineral and bone metabolism, 9 (3). pp. 166-169. ISSN 1971-3266

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Oral bisphosphonates comprise the most widely prescribed class of antiosteoporotic drugs. Recent reports, however, suggest a link between prolonged bisphosphonate use and atypical low-energy, subtrochanteric fractures. We describe the clinical course of two patient treated for a long term with different bisphosphonates who developed subtrochanteric atypical fractures. They were treated initially with intramedullary rodding without pain disappearance or healing of the fracture. Strontium ranelate, a new orally administered agent for the treatment of osteoporosis, was given to these patients with complete closure of the fracture and pain disappearance after a few months. We conclude that based on the chronology of fracture healing and pain disappearance of our patients and published evidence that strontium ranelate can accelerate fracture healing in a rat model, that strontium ranelate had a positive anabolic effect that contributed to fracture healing that produced the secondary disappearance of pain

Item Type: Article
Uncontrolled Keywords: Bisphosphonate, atypical fractures, delayed healing, strontium ranelate
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User: Danilo Dezzi
Date Deposited: 03 Dec 2013 09:49
Last Modified: 03 Dec 2013 09:49
URI: http://eprints.bice.rm.cnr.it/id/eprint/6086

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