Tissue engineering applications in the management of bone loss

Carulli, Christian and Matassi, Fabrizio and Civinini, Roberto and Innocenti, Massimo (2013) Tissue engineering applications in the management of bone loss. Clinical cases in mineral and bone metabolism, 10 (1). pp. 22-25. ISSN 1971-3266

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Abstract

Several conditions in Orthopaedics and Traumatology are characterized by a bone loss. Bone auto- or allo-grafting was considered sufficient to fullfill the defects decades ago; however, large bone defects were challenging for the Surgeons, particularly in case of necessity of structural and biological properties. Bioindusrty proposed over the years synthetic biomaterials, as Demineralized Bone Matrix, bioactive surfaces for implant coponents, and recently recombinant Bone Morphogenetic Proteins. At the same time, the concept of the “biological chamber” and “diamond concept” allowed the scientific community to consider the need of a more complex interaction between scaffolds (matrix), cells (mesenchymal cells), and signaling (growth factors) in order to induce bone regeneration and also to fill small or large bone defects. A brief overview is made on the processes of a physiologic bone metabolism (induction, conduction, osteogenesis), on the latest therapeutical procedures, based on the use of autologous growth factors and cells, and the recent prosthetic or synthetic scaffolds, and the common clinical conditions that may beneficiate of these modern approaches

Item Type:	Article
Uncontrolled Keywords:	Tissue engineering, bone loss, bone graft
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 611 Anatomia; Citologia; Istologia umana > 611.7 Sistema muscoloscheletrico, tegumento
Depositing User:	Danilo Dezzi
Date Deposited:	28 Nov 2013 13:10
Last Modified:	28 Nov 2013 13:10
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6105

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