Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease-free survival and overall survival in patients with gastric carcinoma

Tamburini, Andrea and Orsenigo, Elena and Albarello, Luca and Mazza, E. and Staudacher, Carlo (2009) Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease-free survival and overall survival in patients with gastric carcinoma. Il giornale di chirurgia, 30 (5 Supp). p. 237. ISSN 1971-145X

Preview

Text article(350).pdf - Published Version Download (507kB)

Abstract

ntroduction: Cyclooxygenases regulate the production of prostaglandins and play a role in tumor development and progression. The authors investigated the prognostic impact of expression COX-2 in gastric cancer resected patients. Methods: A cohort of 194 patients with gastric cancer without distant metastasis who underwent R0 gastric resection were enrolled in this study. Association between factors including clinico-pathological variables and COX-2 scores, were assessed. Results: A correlation between COX-2 expression, grading and advanced penetration dept (mean COX-2 expression 74% in early gastric cancer (EGC) versus 52% in non-EGC, p=0.0017). There was an association between COX-2 expression and the presence of lymph-nodes metastasis (p<0,0001, 2) We also observed a significant association between COX-2 expression and relapse of disease (p=0.05 KM) but not with poor survival. Conclusions: High COX-2 protein expression, serosal invasion (pT3-pT4), and presence of lymph-node metastasis are poor prognostic factors in patients with gastric carcinoma without distant metastasis.

Item Type:	Article
Uncontrolled Keywords:	gastric carcinoma, cyclooxygenase-2, prognosis
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	22 Feb 2016 11:55
Last Modified:	22 Feb 2016 11:55
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6359

Actions (login required)

View Item