Preliminary analysis of 30 consecutive neoadjuvant chemotherapy treatments for operable Advanced Gastric Cancer (AGC)

Tamburini, Andrea and Orsenigo, Elena and Gazzetta, Paolo and Mazza, E. and Di Palo, Saverio and Staudacher, Carlo (2009) Preliminary analysis of 30 consecutive neoadjuvant chemotherapy treatments for operable Advanced Gastric Cancer (AGC). Il giornale di chirurgia, 30 (5 Supp). p. 239. ISSN 1971-145X

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Abstract

Introduction: Gastric cancer remains one of the world’s most commonly diagnosed cancers. Standard treatment for highly Advanced Gastric Cancer (AGC) has not been established yet. NeoAdjuvant Chemotherapy (NAC) represents a promising approach, which may improve the prognosis of AGC. Methods: Results for a series of 30 consecutive patients with AGC treated with ECF induction chemotherapy since January 2008 were analyzed retrospectively. Results: The primary tumor was resected in 23 of the 30 patients (resectability, 85.2%). Progression of the disease during chemotherapy was observed in 1 patient only (3,3%). No treatment-related deaths occurred, and serious adverse effects (grade 3-4) were noted in only 13,3 % of the patients. Curative (R0) resection was possible in 20 patients. The downstaging rate was 86.9% (20/23), resulting in a significantly improved prognosis for the downstaged patients (P = 0.012). Conclusion: Induction chemotherapy for AGC appears to be well tolerated, safe and promising treatment.

Item Type:	Article
Uncontrolled Keywords:	advanced gastric cancer, neoadjuvant chemotherapy
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	22 Feb 2016 12:22
Last Modified:	22 Feb 2016 12:22
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6362

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