Continuous leakage monitoring with Sn-medronate - 99mTc - labelled RBC and hand-held gamma-probe during hypertermic isolated limb and lung perfusion

Villa, G. and De Cian, F. and Pomposelli, Elena and Santoni, R. and Bodrato, S. and Sambuceti, G. (2009) Continuous leakage monitoring with Sn-medronate - 99mTc - labelled RBC and hand-held gamma-probe during hypertermic isolated limb and lung perfusion. Il giornale di chirurgia, 30 (5 supp). pp. 240-241. ISSN 1971-145X

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Abstract

The aim of this study was to analyze the value of continuous leakage monitoring with red blood cells (RBC) labelled with 99mTcmedronate and an external scintillation detector (surgical probe) in patients treated with hyperthermic isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF alpha) and melphalan. Systemic hematological and metabolic profiles and tumor response were determined. The mean isotopically measured leakage was 5.8% per hour. The correlation between the monitored systemic activity in the blood by surgical probe and by blood samplings were calculated. A good correlation was observed between the two techniques. Patients with a low leakage rate showed reduced adverse effect. Real time monitoring of the leakage during ILP obtained with this method seems to be in our experience easy, safe and accurate, and serves as a good guide for the effectiveness of isolation during perfusion.

Item Type:	Article
Uncontrolled Keywords:	99mTc-medronate, surgical probe, isolated limb perfusion, tumor necrosis factor-alpha, melphalan, leakage
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User:	Nadia Del Gobbo
Date Deposited:	22 Feb 2016 12:23
Last Modified:	22 Feb 2016 12:23
URI:	http://eprints.bice.rm.cnr.it/id/eprint/6363

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