Production of cytokines at the operation site

Di Vita, Gaetano and Patti, Rosalia and Vetri, Giuseppe and Macchiarella, B. and D'Agostino, Pietro and Caruso, Giuseppe B. and Ferlazzo, Viviana and Arcoleo, Francesco and Sammartano, Sergio and Angileri, Mariangela and Cillari, Enrico (2005) Production of cytokines at the operation site. Il giornale di chirurgia, 26 (6-7). pp. 241-245. ISSN 1971-145x

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Background and aim: Cytokines are part of a family of molecules involved in the initiation, control and termination of the events that occurs in wound healing process. Aim of this study was to evaluate the production of some cytokines [interleukin (IL)-6, IL-10, IL-1a, IL-1ra, interferon (IFN)-g] in the drainage wound fluid from patients undergoing incisional hernia repair. Methods: Ten female patients with abdominal midline incisional hernia undergoing to surgical repair were included in this study. In all cases a closed suction drain was placed in the wound below the fascia and it was removed on the 4 th postoperative day. Wound fluid was collected on the 1st , 2 nd, 3rd and 4th day and its amount in each time was recorded. The production of IL-6, IL-10, IL-1a, IL-1ra and IFN-g were evaluated as quantity produced in 24 hour. Results: In all patients the amount of drain fluid from surgical wound was highest on the 1st day after surgery, afterwards there is a significant reduction. The production of all cytokines evaluated was highest on the 1st day decreasing on the 2nd day except for IL-1a that not show any modification. The produciton of IL-1ra, IL-6, IL-1a and IL-10 was significantly reduced on the 3rd and 4th postoperative day in comparison with the respectively values recorded on the 1st day, whereas IFN-g levels were similar. Conclusions: The dosage of cytokines in the drain fluid led us to better evaluated the events that follow surgical wound and their analysis offers further information in the role of cytokines in healing process, with the goal to get supportive treatments to promote the best evolution.

Item Type: Article
Uncontrolled Keywords: Cytokines, Incisional hernia; Citochine, Laparocele
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User: Chiara D'Arpa
Date Deposited: 15 Nov 2013 13:53
Last Modified: 15 Nov 2013 13:53

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