Cortisone-induced gigantomastia during chemotherapy

Troccola, Antonietta and Maruccia, Michele and Dessy, Luca Andrea and Onesti, Maria Giuseppina (2011) Cortisone-induced gigantomastia during chemotherapy. Il giornale di chirurgia, 32 (5). pp. 266-269. ISSN 1971-145X

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Gigantomastia is a rare, psychologically and physically disabling condition characterized by excessive breast growth. There is no universal consensus on the definition of gigantomastia, but it is most commonly described as breast enlargement that requires removal ranging from 800 to 2000 g, or even a D cup bra size. It typically occurs in the setting of marked hormonal changes such as puberty and pregnancy; however, there have also been a number of reports of gigantomastia in the setting of autoimmune diseases. Rare association of gigantomastia included medicinal aetiologies such as penicillamine, neothetazone, and cyclosporine. The mechanism of action of these pharmacological agents remains unclear. We report the first case of gigantomastia associated with cortisone in the setting of ovary cancer treated with chemotherapy cycles after hysterectomy and bilateral adnexectomy. Moreover, we propose a clinic evidence and a metabolic theory to explain this association.

Item Type: Article
Uncontrolled Keywords: Gigantomastia - Ipertrofia mammaria - Tumore dell’ovaio - Terapia cortisonica - Chemioterapia
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User: Nadia Del Gobbo
Date Deposited: 05 May 2016 10:59
Last Modified: 05 May 2016 10:59

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