Which therapy to prevent post-thyroidectomy hypocalcemia?

Pisaniello, Donatella and Parmeggiani, Domenico and Piatto, Alberto and Avenia, Nicola and d'Ajello, M. and Monacelli, Massimo and Calzolari, Filippo and Sanguinetti, Alessandro and Parmeggiani, Umberto and Sperlongano, Pasquale (2005) Which therapy to prevent post-thyroidectomy hypocalcemia? Il giornale di chirurgia, 26 (10). pp. 357-361. ISSN 1971-145x

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Hypocalcemia is one of the most frequent complications after total extracapsular thyroidectomy (TET). In most of cases it is a transient phenomenon. The aim of this study is to evaluate if and how the oral administration of calcium or calcium combined with D-vitamin could effectively prevent post-thyroidectomy hypocalcemia. A randomized prospective study was performed, recruiting 120 patients who underwent total thyroidectomy.The patients in our series were randomly assigned to one of two groups: group A - patients who received calcium lactogluconate/ calcium carbonate (mg 300 per day); group B - patients who received calcium carbonate/cholecalciferol therapy (calcium carbonate: 1500 mg per day; cholecalciferol 400 UI per day). The groups were well mateched for age, sex and pathologies. Patients of both A and B groups were divided in two subgroups: those operated on for benign thyroid diseases (A1 and B1) and those operated on for malignancy (A2, B2). Serum calcium assays, performed 24, 48 and 72 hours after surgery, showed mean values of calcemia higher in patients of the B1 and B2 group. Statistical analysis was performed using a Student's t test. Mean serum calcium concentrations on post-operative day one, two and three were higher in patients of the group B (p<<0.01). Early and combined oral administration of both calcium and vitamin D seemed to prove major efficacy in preventing and treating post-operative hypocalcemia, showing mean serum calcium levels higher than those of patients who received only oral calcium administration. Nevertheless, further studies are necessary to validate these data

Item Type: Article
Uncontrolled Keywords: Thyroidectomy, Hypocalcemia, Hypoparathyroidism, D-vitamin, Calcium
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User: Chiara D'Arpa
Date Deposited: 27 Nov 2013 17:38
Last Modified: 27 Nov 2013 17:38
URI: http://eprints.bice.rm.cnr.it/id/eprint/7912

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