Effects of Gaps Induced Into the ACL Tendon Graft on Tendon-Bone Healing in a Rodent ACL Reconstruction Model

Lovric, Vedran and Kanazawa, Tomonoshin and Nakamura, Yoshinari and Oliver, Rema A. and Yu , Yu and Walsh, William Robert (2011) Effects of Gaps Induced Into the ACL Tendon Graft on Tendon-Bone Healing in a Rodent ACL Reconstruction Model. M.L.T.J. Muscles, Ligaments and Tendons Journal, 1 (3). pp. 91-99. ISSN 2240-4554

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Graft necrosis following ACL reconstruction is often associated with the use of autologous grafts. Host cells rather than graft cells contribute to the repair of the tendon-bone interface and the remodeling of the autologous graft. The native tendonbone interface is not recreated and the biomechanical properties are not restored back to native values. We examined the effects of introducing gaps within the tendon graft prior to ACL reconstruction in a rodent model. We hypothesised that gaps will make physical way for host cells to infiltrate and repopulate the graft and thus enhance healing. Animals were sacrificed at seven, fourteen, and twenty-eight days for biomechanical testing and histology. Our findings indicate that graft necrosis, usually observed in the initial two weeks of the healing process, is averted. Histological observations showed that tendon-bone healing stages were hastened however this didn’t translate into improved biomechanical properties.

Item Type: Article
Uncontrolled Keywords: ACL reconstruction, graft cells, graft necrosis, host cells, rodent model, tendon-bone healing
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User: Danilo Dezzi
Date Deposited: 27 Mar 2014 15:14
Last Modified: 27 Mar 2014 15:14
URI: http://eprints.bice.rm.cnr.it/id/eprint/7954

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