Medullary thyroid carcinoma: state of the art

Favia, Gennaro and Iacobone, Maurizio (2005) Medullary thyroid carcinoma: state of the art. Il giornale di chirurgia, 26 (11/12). pp. 405-409. ISSN 1971-145x

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Medullary thyroid carcinoma (MTC) constitutes about 3-10% of all thyroid cancers. It arises from the parafollicular C cells that produce calcitonin (CT) and occurs as a sporadic form. or less commonly, as a hereditary form, as part of multiple endocrine neoplasia syndromes types 2A (MEN 2A) and 2B (MEN 2B). The hereditary forms are autosomal dominant traits associated with germline mutations of RET proto-oncogene. Progresses in genetics have permitted an improvement of management, screening and treatment. Surgery is the only successful treatment for MTC, as there is no effective adjuvant therapy for residual disease. A total thyroidectomy and vigilant management and surveillance of the neck are recommended. Interdisciplinary management including surgeons, endocrinologists, pathologists, radiotherapists, radiologists, and oncologists should be considered.

Item Type: Article
Additional Information: Editoriale
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia
Depositing User: Chiara D'Arpa
Date Deposited: 03 Sep 2014 09:05
Last Modified: 03 Sep 2014 09:05

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