Proteomic profiling of skeletal muscle plasticity

Ohlendieck, Kay (2011) Proteomic profiling of skeletal muscle plasticity. M.L.T.J. Muscles, Ligaments and Tendons Journal, 1 (4). pp. 119-126. ISSN 2240-4554

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Abstract

ne of the most striking physiological features of skeletal muscle tissues are their enormous capacity to adapt to changed functional demands. Muscle plasticity has been extensively studied by histological, biochemical, physiological and genetic methods over the last few decades. With the recent emergence of high-throughput and large-scale proteomic techniques, mass spectrometry-based surveys have also been applied to the global analysis of the skeletal muscle protein complement during physiological modifications and pathophysiological alterations. This review outlines and discusses the impact of recent proteomic profiling studies of skeletal muscle transitions, including the effects of chronic electro-stimulation, physical exercise, denervation, disuse atrophy, hypoxia, myotonia, motor neuron disease and age-related fibre type shifting. This includes studies on the human skeletal muscle proteome, animal models of muscle plasticity and major neuromuscular pathologies. The biomedical importance of establishing reliable biomarker signatures for the various molecular and cellular transition phases involved in muscle transformation is critically examined

Item Type:	Article
Uncontrolled Keywords:	Mass spectrometry; muscle plasticity; muscle proteomics; muscle transformation; muscle transition; skeletal muscle proteome
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	07 Apr 2014 15:52
Last Modified:	07 Apr 2014 15:52
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8017

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