Biological aspects of rotator cuff healing

Wildemann, Britt and Klatte, Franka (2011) Biological aspects of rotator cuff healing. M.L.T.J. Muscles, Ligaments and Tendons Journal, 1 (4). pp. 161-168. ISSN 2240-4554

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Abstract

Tendon tears of the rotator cuff show a high prevalence in today’s population. Patients suffer from permanent pain and disability, and surgical reconstruction may be the only possibility for abatement. The complex process of tendon-bone healing leads to mechanically inferior scar-tissue, which often results in retears or non-healing. In the current literature, factors such as patients age, sex and fatty muscle infiltration are highly correlated to the presence of rotator cuff tears and the incidence of retears. To improve the tendon tissue quality after surgical reconstructions biologically based strategies with use of growth factors arouse more and more interest in the last years. However, to optimize the treatment of rotator cuff tears the biological background of tears and retears must be investigated in more detail. This article will elucidate different aspects that have an impact on rotator cuff healing and give a brief insight in tendon/ligament cell culture and animal studies focusing on growth factor treatments.

Item Type:	Article
Uncontrolled Keywords:	Age, fatty infiltration, growth factors, rotator cuff rupture, sex, tenocytes
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	07 Apr 2014 16:27
Last Modified:	07 Apr 2014 16:27
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8023

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