Syndecans in skeletal muscle development, regeneration and homeostasis

Pisconti, Addolorata and Bernet, Jennifer D. and Olwin, Bradley B. (2012) Syndecans in skeletal muscle development, regeneration and homeostasis. M.L.T.J. Muscles, Ligaments and Tendons Journal, 2 (1). pp. 1-9. ISSN 2240-4554

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Abstract

Skeletal muscle is a highly dynamic tissue that can change in size in response to physiological demands and undergo successful regeneration even upon extensive injury. A population of resident stem cells, termed satellite cells, accounts for skeletal muscle plasticity, maintenance and regeneration. Mammalian satellite cells, generated from muscle precursor cells during development, are maintained quiescent in the musculature throughout a lifespan, but ready to activate, proliferate and differentiate into myocytes upon demand. Syndecans are transmembrane heparan sulfate proteoglycans expressed in muscle precursors during embryonic development and in satellite cells during postnatal life. In the last decades a number of crucial functions for syndecans in myogenesis and muscle disease have been described. Here we review the current knowledge of the multiple roles played by syndecans in the skeletal muscle of several animal models and explore future perspectives for human muscle health, with a focus on muscle aging and muscular dystrophy

Item Type:	Article
Uncontrolled Keywords:	Syndecans, satellite cells, myogenesis, muscular dystrophy, aging, muscle regeneration
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	16 Apr 2014 14:48
Last Modified:	16 Apr 2014 14:48
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8028

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