The development of the myotendinous junction. A review

Charvet, Benjamin and Ruggiero, Florence and Le Guellec, Dominique (2012) The development of the myotendinous junction. A review. M.L.T.J. Muscles, Ligaments and Tendons Journal, 2 (2). pp. 53-63. ISSN 2240-4554

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Abstract

The myotendinous junction (MTJ) is a complex specialized region located at the muscle-tendon interface that represents the primary site of force transmission. Despite their different embryologic origins, muscle and tendon morphogenesis occurs in close spatial and temporal association. After muscle attachment, muscle and tendon constitute a dynamic and functional integrated unit that transduces muscle contraction force to the skeletal system. We review here the current understanding of MTJ formation describing changes during morphogenesis and focusing on the crosstalk between muscle and tendon cells that leads to the development of a functional MTJ. Molecules involved in the formation of the linkage, both at the tendon side and at the muscle side of the junction are described. Much of this knowledge comes from studies using different animal models such as mice, zebrafish and Drosophila where powerful methods for in vivo imaging and genetic manipulations can be used to enlighten this developmental process

Item Type:	Article
Uncontrolled Keywords:	Myotendinous junction, DGC, basement membrane, integrin, collagen, development
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	16 Apr 2014 15:13
Last Modified:	16 Apr 2014 15:13
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8063

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