Stem cell research and clinical development in tendon repair

Filomeno, Paola and Dayan, Victor and Touriño, Cristina (2012) Stem cell research and clinical development in tendon repair. M.L.T.J. Muscles, Ligaments and Tendons Journal, 2 (3). pp. 204-211. ISSN 2240-4554

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Abstract

Stem cells are one of the most fascinating areas in regenerative medicine today. They play a crucial role in development and regeneration and are defined as cells that continuously reproduce themselves while maintaining the ability to differentiate into various cell types. Stem cells are found at all developmental stages, from embryonic stem cells (ESCs) which differentiate into all cell types, to adult stem cells (ASCs) which are responsible for tissue regeneration. Studies using animal models have shown promising results following cell therapy for induced injury in musculoskeletal system, including tendon healing, but the results can be variable. Alternative sources for cell therapy in tendon pathology may include ESCs, ASCs (bone marrow, adipose tissue or tendon derived stem cells) or induced pluripotent stem cells (iPSCs). While ethical and safety concerns currently forbid clinical application of ESCs and iPSCs, initial clinical trials with ASCs are promising

Item Type:	Article
Uncontrolled Keywords:	Cell therapy,embryonic stem cell, induced pluripotent stem cells
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	16 Apr 2014 16:25
Last Modified:	16 Apr 2014 16:25
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8144

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