Mesenchymal stem cell applications to tendon healing

Chaudhury, Salma (2012) Mesenchymal stem cell applications to tendon healing. M.L.T.J. Muscles, Ligaments and Tendons Journal, 2 (3). pp. 222-229. ISSN 2240-4554

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Tendons are often subject to age related degenerative changes that coincide with a diminished regenerative capacity. Torn tendons often heal by forming scar tissue that is structurally weaker than healthy native tendon tissue, predisposing to mechanical failure. There is increasing interest in providing biological stimuli to increase the tendon reparative response. Stem cells in particular are an exciting and promising prospect as they have the potential to provide appropriate cellular signals to encourage neotendon formation during repair rather than scar tissue. Currently, a number of issues need to be investigated further before it can be determined whether stem cells are an effective and safe therapeutic option for encouraging tendon repair. This review explores the in-vitro and invivo evidence assessing the effect of stem cells on tendon healing, as well as the potential clinical applications

Item Type: Article
Uncontrolled Keywords: Tendon, rotator cuff, stem cell, regeneration, cytokines
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User: Danilo Dezzi
Date Deposited: 16 Apr 2014 16:30
Last Modified: 16 Apr 2014 16:30

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