Surgical treatment of papillary thyroid carcinoma without lymph nodal involvement

Conzo, Giovanni and Docimo, Giovanni and Ruggiero, Roberto and Napolitano, Salvatore and Palazzo, Antonietta and Gambardella, C. and Mauriello, C. and Tartaglia, Ernesto and Cavallo, F. and Santini, Luigi (2012) Surgical treatment of papillary thyroid carcinoma without lymph nodal involvement. Il giornale di chirurgia, 33 (10). pp. 339-342. ISSN 1971-145X

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Background. In the treatment of differentiated thyroid cancer (DTC), in absence of enlarged lymph nodes, the role of routine central lymph node dissection (RCLD) remains controversial. The aim of this study is to analyze data resulting from total thyroidectomy (TT) not combined with RCLD in the treatment of DTC. Methods. We retrospectively evaluated the clinical records of 80 patients treated between January 1996 and December 2003 with TT without RCLND, in absence of suspected enlarged lymph nodes at preoperative ultrasonography and intraoperatively during neck exploration. In this series, 75 patients (93.7%) underwent radioiodine (RAI) ablation, followed by Thyroid Stimulating Hormone (TSH) suppression therapy. In case of locoregional lymph nodal recurrence, a central (VI) and ipsilateral (III-IV) selective lymph node dissection was performed. Results. Incidence of permanent hypoparathyroidism (iPTH < 10 pg/ml) and unilateral temporary vocal fold paralysis were respectively 2.55% and 2.55%. Locoregional recurrence, with positive cervical lymph nodes, after a 10.3 ± 4.7 years mean follow-up was observed in 3 patients (3.75%). They were submitted to a central (VI) and ipsilateral (III-IV) selective neck dissection without significant complications. Conclusions. In our series, TT not combined with RCLD was associated to a low locoregional recurrence rate, even if the lack of a control group treated with RCLD does not allow any generalized assumption. RCLD may be indicated in high risk patients, in whom lymph nodal recurrence is more frequent. More prospective randomized studies are needed to better define the role of RCLD and postoperative radioiodine ablation.

Item Type: Article
Uncontrolled Keywords: Total thyroidectomy, Papillary thyroid cancer, Routine central lymph node dissection, Radioactive iodine ablation
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 617 Rami vari della medicina; Chirurgia > 617.4 Chirurgia secondo il Sistema e Regioni
Depositing User: Nadia Del Gobbo
Date Deposited: 03 Aug 2016 15:18
Last Modified: 03 Aug 2016 15:18

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