Specialisation of extracellular matrix for function in tendons and ligaments

Birch, Helen L. and Thorpe, Chavaunne T. and Rumian, Adam P. (2013) Specialisation of extracellular matrix for function in tendons and ligaments. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (1). pp. 12-22. ISSN 2240-4554

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Abstract

Tendons and ligaments are similar structures in terms of their composition, organisation and mechanical properties. The distinction between them stems from their anatomical location; tendons form a link between muscle and bone while ligaments link bones to bones. A range of overlapping functions can be assigned to tendon and ligaments and each structure has specific mechanical properties which appear to be suited for particular in vivo function. The extracellular matrix in tendon and ligament varies in accordance with function, providing appropriate mechanical properties. The most useful framework in which to consider extracellular matrix differences therefore is that of function rather than anatomical location. In this review we discuss what is known about the relationship between functional requirements, structural properties from molecular to gross level, cellular gene expression and matrix turnover. The relevance of this information is considered by reviewing clinical aspects of tendon and ligament repair and reconstructive procedures

Item Type:	Article
Uncontrolled Keywords:	Musculoskeletal, tendon, ligament, biomechanics
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 11:02
Last Modified:	17 Apr 2014 11:02
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8224

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