Nanomechanics of collagen microfibrils

Vesentini, Simone and Redaelli, Alberto and Gautieri, Alfonso (2013) Nanomechanics of collagen microfibrils. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (1). pp. 23-24. ISSN 2240-4554

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Abstract

Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to organisms and is thus the prime construction material in biology. Collagen is also the dominating material in the extracellular matrix where its stiffness controls cell differentiation, growth and pathology. We use atomistic-based hierarchical multiscale modeling to describe this complex biological material from the bottom up. This includes the use and development of large-scale computational modeling tools to investigate several aspects related to collagen-based tissues, including source of visco-elasticity and deformation mechanisms at the nanoscale level. The key innovation of this research is that until now, collagen materials have primarily been described at macroscopic scales, without explicitly understanding the mechanical contributions at the molecular and fibrillar levels. The major impact of this research will be the development of fundamental models of collagenous tissues, important to the design of new scaffolding biomaterials for regenerative medicine as well as for the understanding of collagen-related diseases

Item Type:	Article
Uncontrolled Keywords:	Atomistic simulations, biomechanics, collagen
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 11:04
Last Modified:	17 Apr 2014 11:04
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8225

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