Sample size determination for clinical research

Wang, Duolao and Bakhai, Ameet and Del Buono, Angelo and Maffulli, Nicola (2013) Sample size determination for clinical research. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (3). pp. 116-117. ISSN 2240-4554

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Abstract

Calculating the sample size is a most important determinant of statistical power of a study. A study with inadequate power, unless being conducted as a safety and feasibility study, is unethical. However, sample size calculation is not an exact science, and therefore it is important to make realistic and well researched assumptions before choosing an appropriate sample size accounting for dropouts and also including a plan for interim analyses during the study to amend the final sample size

Item Type:	Article
Uncontrolled Keywords:	Randomized control trials, statistics, sample size
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 14:15
Last Modified:	17 Apr 2014 14:15
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8248

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