Is there a correlation between biophotonical, biochemical, histological, and visual changes in thecartilage of osteoarthritic knee-joints?

Stumpfe, Stephanie Tatjana and Pester, Julia Karin and Steinert, Susanne and Marintschev, Ivan and Plettenberg, Holger and Aurich, Matthias and Hofmann, Gunther Olaf (2013) Is there a correlation between biophotonical, biochemical, histological, and visual changes in thecartilage of osteoarthritic knee-joints? M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (3). pp. 157-165. ISSN 2240-4554

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Abstract

The aim of this study was to detect characteristic structural changes in the cartilage composition of osteoarthritis (OA), hereby improving the arthroscopic identification of cartilage pathology by the use of a non-destructive technique - NIRS (Near-Infrared Spectroscopy). 682 cartilage samples out of 25 knees with OA were classified visually, using the ICRS system, biophotonically, histologically (n = 66), using the Score of Mankin and the Score of Otte, and biochemically (n = 616), determining the content of glycosaminoglycan (GAG) and hydroxyproline (HP). Significant correlations were found between biophotonical, histological, biochemical and visual characteristics of cartilage lesions. NIRS values corresponded to the content of GAG, HP and to the Score of Mankin and Otte. The data show that changes in the composition and structure of articular cartilage influence the optical properties and can be measured objectively by NIRS. The ease of use during arthroscopy, the quick response and the non-destructive nature of NIRS make it a promising addition to the assessment of disease intervention in OA

Item Type:	Article
Uncontrolled Keywords:	Cartilage, GAG, hydroxyproline, Mankin score
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 14:33
Last Modified:	17 Apr 2014 14:33
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8271

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