Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep

Van Kampen, Craig and Arnoczky, Steven and Parks, Patrick and Hackett, Eileen and Ruehlman, Dana and Turner, Anthony and Schlegel, Theodore (2013) Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep. M.L.T.J. Muscles, Ligaments and Tendons Journal, 3 (3). pp. 229-235. ISSN 2240-4554

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Abstract

To determine if an absorbable collagen scaffold of high porosity would allow rapid tissue ingrowth and permit the functional maturation and alignment of tendon-like tissue, scaffolds were sutured to the superficial surface of the infraspinatus tendons of adult sheep. Histology demonstrated complete ingrowth with fibrovascular tissue by 6 weeks and by 12 weeks the scaffold had induced the formation of a layer of dense, regularly-oriented collagenous tissue which significantly increased the thickness of the native tendon. This new tissue was well-integrated into the host tissues at both the bone interface and along the length of the tendon. At 26 weeks the scaffold was completely absorbed leaving a stable layer of mature tendon-like tissue over the surface of the host tendon which was still present at 52 weeks. The use of a reconstituted collagen scaffold consistently increased the thickness of a rotator cuff tendon by inducing the formation of a well-integrated and mature tendon-like tissue

Item Type:	Article
Uncontrolled Keywords:	Tendon, collagen scaffold, rotator cuff
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 15:37
Last Modified:	17 Apr 2014 15:37
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8334

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