Bone tissue: hormonal regulating systems, growth factors and remodeling as a target for therapeutic agents in osteoporosis

Lello, Stefano and Guardianelli, Francesca and Mosca, Luciana (2012) Bone tissue: hormonal regulating systems, growth factors and remodeling as a target for therapeutic agents in osteoporosis. Multidisciplinary Journal of Women's Health (MJWH), 1 (1). pp. 14-18. ISSN 2281-3403

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Abstract

Bone regulating systems have received growing attention in recent years. Regulation of skeletal pathophysiology and modulation of osteoblast, osteoclast and osteocyte activity by hormones, cytokines, and growth factors are not only important features of bone biology, but also a target for old and new osteoporosis therapies. Molecules such as selective estrogen receptor modulators (SERMs, e.g. raloxifene and bazedoxifene), denosumab, or bisphosphonates may exert their effects through modulation of estrogen receptor, RANKL and osteoclast activity, respectively. Knowledge of the regulating systems is also the basis for developing future therapy. This review shows regulating systems as a basis for current and future therapies in the field of osteoporosis

Item Type:	Article
Uncontrolled Keywords:	Osteoblast, osteoclast, osteocyte
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 16:07
Last Modified:	18 Apr 2014 09:49
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8382

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