Cardiovascular risk factors in postmenopausal women: effects of estrogen therapy on glucose and lipid profiles

Villa, Paola and Moruzzi, Maria Cristina and Lassandro, Anna Pia and Sagnella, Francesca and Riccardi, Maria Teresa and Vacca, Lorenzo and Salerno, Giovanna and Scambia, Giovanni (2012) Cardiovascular risk factors in postmenopausal women: effects of estrogen therapy on glucose and lipid profiles. Multidisciplinary Journal of Women's Health (MJWH), 1 (1). pp. 26-32. ISSN 2281-3403

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Abstract

The menopause is associated with unfavorable changes in the lipid profile as well as in glucose metabolism, which may help to increase the incidence of cardiovascular diseases. The metabolic impact of hormone replacement therapy differs in relation to the dose of the estrogen component, the type of progestin, and the route of administration used. Since most studies analyze the effect of combined estro-progestin therapy, the impact of the estrogen component alone is not always differentiable, however the main results are generally consistent. A review of the recent literature was conducted to analyze the impact of estrogen replacement therapy (ERT) on glucose and lipid metabolism and the differences linked to different doses, associations and routes of administration. Studies were selected on the basis of quality of data and relevance to the present topic. Many studies showed that both oral and transdermal estrogen therapy induced positive effects on glucose metabolism, with minimal changes and differences between treatments. A considerable amount of data documented increases in HDL and decreases in LDL cholesterol. Low-dose estrogen therapy showed no negative effect on triglycerides and a neutral effect on the whole lipid panel. In conclusion, low-dose ERT may prevent the physiological worsening of glucose and lipid metabolism in menopausal women without showing any significant negative effects

Item Type:	Article
Uncontrolled Keywords:	Estrogen replacement therapy, glucose
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	17 Apr 2014 16:17
Last Modified:	18 Apr 2014 09:49
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8386

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