Molecular biology of the parathyroid hormone: biological actions

Potts, John T. (2004) Molecular biology of the parathyroid hormone: biological actions. Clinical cases in mineral and bone metabolism, 1 (2). pp. 93-98. ISSN 1971-3266

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Parathyroid hormone (PTH); the principal parathyroid hormone receptor (PTH1R); a G protein-linked heptahelical membrane receptor; and a second heptahelical receptor, the calcium- sensing receptor (CaR) through a tightly-regulated endocrine feedback system together constitute the principal regulators of calcium homeostasis. The effectors of the calcium regulation are coordinated responses in target tissues.These responses as well as hormone biosynthesis, secretion and signaling are all under precise genetic control. Inactivatin gmutations in these genes controlling the multi-step process ofcalcium homeostasis lead to hypocalcemic disorders, as outlined in accompanying articles.

Item Type: Article
Uncontrolled Keywords: Parathyroid hormone, parathyroid hormone receptor, calcium-sensing receptor, calcium homeostasis
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User: Danilo Dezzi
Date Deposited: 18 Apr 2014 12:25
Last Modified: 18 Apr 2014 12:25

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