Cushing syndrome, metabolic syndrome and inflammation: a suggested way out

Esposito, Katherine and Bellastella, Giuseppe and Maiorino, Maria Ida and Pivonello, Rosario and Colao, Annamaria and Giugliano, Dario (2013) Cushing syndrome, metabolic syndrome and inflammation: a suggested way out. Reviews in endocrinology and metabolism, 1 (1). pp. 41-45. ISSN 2282-8362

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Endogenous hypercortisolism is associated with an increased cardiovascular risk. Cushing Syndrome (CS) shares many clinical features with metabolic syndrome, including abdominal obesity, systemic arterial hypertension, insulin resistance, dyslipidemia, and thrombotic diatesis. Moreover, CS represents an interesting pattern of an endocrine disorder associated with chronic lowgrade inflammation which is not blunted by the resolution of hypercortisolism. The proinflammatory state that accompanies the metabolic syndrome may provide a connection between CS, inflammation and metabolic processes, which is highly deleterious for vascular functions. There is evidence that dietary patterns similar to those of the Mediterranean-style diet exert ositive effects on almost all components of the metabolic syndrome and other conditions associated with, including inflammation, insulin resistance, and endothelial dysfunction. Therefore, an intervention strategy based on lifestyle changes may play a role in patients with resolution of hypercortisolism in which the anti-inflammatory effects of cortisol are lost and cytokines levels are increased. In this setting, the Mediterranean healthy dietary pattern may represent an innovative approach in order to improve the disease course and to reduce in the long term the cardiovascular risk of people affected by CS

Item Type: Article
Uncontrolled Keywords: Cushing syndrome, metabolic syndrome, chronic low-grade inflammation, mediterranean diet
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.4 Malattie del sistema emopoietico, linfatico, ghiandolare; Malattie del sistema endocrino
Depositing User: Matteo Viola
Date Deposited: 17 Jun 2014 13:05
Last Modified: 17 Jun 2014 13:05

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