Bone mineral density and bone structure in primary hypoparathyroidism

Kwok-Wing Chan, Fredriech (2004) Bone mineral density and bone structure in primary hypoparathyroidism. Clinical cases in mineral and bone metabolism, 1 (2). pp. 123-126. ISSN 1971-3266

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Since parathyroid hormone has dual properties on bone, both catabolic and anabolic, it is interesting to review how the bone mineral density and structure change in patients with chronic hypoparathyroidism. Others and we have demonstrated consistently that the state of chronic hypoparathyroidism is associated with increased BMD, most notably at the spine. Those with idiopathic hypoparathyroidism have a similar degree of increase in BMD as those with postthyroidectomy hypoparathyroidism. Both groups also have significantly lower level of biochemical markers such as osteocalcin, bone-specific alkaline phosphatase activity and urinary resorption markers as compared with controls. This reflects the low rate of bone remodeling and implies a significant reduction in “birth rate” of bone modeling units and prolongs the “life span” of the basic structural unit. It therefore allows for more complete secondary mineralization. The reduction in bone remodeling is further confirmed by bone histomorphometry. The observed effect on BMD is likely a result of the combined effects of decreased bone resorption due to hypoparathyroidism and the improvement in bone mineralization as a result of continuous treatment with calcitriol and calcium

Item Type: Article
Additional Information:
Uncontrolled Keywords: hypoparathyroidism, bone mineral density, biochemical mark-ers, bone histomor phometry, bone geometry
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User: Danilo Dezzi
Date Deposited: 18 Apr 2014 13:22
Last Modified: 18 Apr 2014 13:22

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