Cell therapies in hypoparathyroidism

Jork, Anette and Glöckner, Herma and Thürmer, Frank and Ulrich, Frank and Brandi, Maria Luisa (2004) Cell therapies in hypoparathyroidism. Clinical cases in mineral and bone metabolism, 1 (2). pp. 163-166. ISSN 1971-3266

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Abstract

Identification of a biocompatible immunoprotective membrane to prevent graft rejection remained elusive until the development of microcapsules formulated in alginate. We report in vit - ro parathyroid hormone secretion from encapsulated human parathyroid tissue using a highly biocompatible alginate produced under GMP conditions. The in vitro function of human parathyroid tissue fragments was maintained after 8 days of culture of alginate microcapsules in serum-free conditions. The structural features of parathyroid tissue was maintained in these culture conditions. Using a biopolymer of clinical grade may be a crucial step toward a clinical use of this technique in parathyroid allotransplantion without immunosuppression

Item Type:	Article
Uncontrolled Keywords:	Arathyroid tissue, parathyroid cells, hypoparathyroidism, alginate, cell therapies
Subjects:	600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User:	Danilo Dezzi
Date Deposited:	22 Apr 2014 16:32
Last Modified:	22 Apr 2014 16:32
URI:	http://eprints.bice.rm.cnr.it/id/eprint/8769

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