Partnership between platelet-rich plasma and mesenchymal stem cells: in vitro experience

Rubio-Azpeitia, Eva and Andia, Isabel (2014) Partnership between platelet-rich plasma and mesenchymal stem cells: in vitro experience. M.L.T.J. Muscles, Ligaments and Tendons Journal, 4 (1). pp. 52-62. ISSN 2240-4554

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We aim to identify current in vitro research exploring platelet-rich plasma (PRP) effects in human Mesenchymal Stem Cells (MSCs) that may encourage or limit the clinical application of MSCs along with PRP. After a systematic search, we identified 57 in vitro studies, focused on optimization of MSC manufacturing, and expanding knowledge about how PRP modifies MSCs behavior for translational purposes. Influences of PRP on proliferation, migration, stemness, preservation of MSC immune-modulatory properties and appearance of senescence phenotype have been explored. Overall PRP stimulates MSC proliferation, preserves MSCs multipotency and does not interfere with any lineage differentiation. PRP (as platelet lysate or releasate) preserves the immune-privileged potential of MSCs and may delay the appearance of the senescent phenotype. Currently there are few data linking precise molecules and biological mechanisms. Various gaps of knowledge need to be addressed in order to obtain enough useful information for translational purposes

Item Type: Article
Uncontrolled Keywords: Cell culture, in vitro, mesenchymal stem cells (MSC), platelet-rich plasma (PRP), regenerative medicine, tissue engineering
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) > 616.7 Malattie del sistema muscoloscheletrico
Depositing User: Danilo Dezzi
Date Deposited: 11 Nov 2014 10:53
Last Modified: 11 Nov 2014 10:53

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