Cortical excitability and neurology: insights into the pathophysiology

Badawy, Radwa A.B. and Loetscher, Tobias and Macdonell, Richard A.L. and Brodtmann, Amy (2012) Cortical excitability and neurology: insights into the pathophysiology. Functional Neurology, 27 (3). pp. 131-145. ISSN 1971-3274

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Transcranial magnetic stimulation (TMS) is a technique developed to non-invasively investigate the integrity of human motor corticospinal tracts. Over the last three decades, the use of stimulation paradigms including single-pulse TMS, paired-pulse TMS, repetitive TMS, and integration with EEG and functional imaging have been developed to facilitate measurement of cortical excitability. Through the use of these protocols, TMS has evolved into an excellent tool for measuring cortical excitability. TMS has high sensitivity in detecting subtle changes in cortical excitability, and therefore it is also a good measure of disturbances associated with brain disorders. In this review, we appraise the current literature on cortical excitability studies using TMS in neurological disorders. We begin with a brief overview of current TMS measures and then show how these have added to our understanding of the underlying mechanisms of brain disorders.

Item Type: Article
Uncontrolled Keywords: cortical excitability, neurological disorders, transcranial magnetic stimulation
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
Depositing User: Marina Spanti
Date Deposited: 17 Dec 2015 14:47
Last Modified: 17 Dec 2015 14:47

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