TAFRO Syndrome in a Patient of South-American Descent

Finocchietto, Paola and Contardo, Damián and Uehara, Tatiana and Papini, Claudia and Deligiannis, Natalia and Darderes, Enrique and Castroagudin, Augusto and Cabral, Cecilia and Di Fonzo, Horacio (2015) TAFRO Syndrome in a Patient of South-American Descent. European Journal of Case Reports in Internal Medicine, 2 (4). pp. 1-3. ISSN 2284-2594

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A 31-year-old Caucasian woman of South-American descent was diagnosed with a variant of multicentric Castleman disease (MCD) that has been reported in Japan as Castleman-Kojima disease. This is a systemic inflammatory disorder known as TAFRO Syndrome which includes thrombocytopenia, polyserositis (ascites/pleural effusion), microcytic anemia, myelofibrosis, fever, renal dysfunction and organomegaly, with immunologic disorder, polyclonal hypergammaglobulinemia, and elevated levels of interleukin-6 (IL-6) and the vascular endothelial growth factor present in serum and/or effusions. Optimal therapies are not well established. The patient was treated with methylprednisolone and rituximab. Following the start of treatment, the patient has been asymptomatic for over 8 months.

Item Type: Article
Uncontrolled Keywords: Castleman disease, TAFRO syndrome
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Chiara D'Arpa
Date Deposited: 14 Sep 2016 13:13
Last Modified: 14 Sep 2016 13:13
URI: http://eprints.bice.rm.cnr.it/id/eprint/15039

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