Remondini, Daniel and Verondini, E. and Lescai, F. and Zironi, I. and Castellani, G. (2009) Network approaches to Genome-Wide Association studies. Il nuovo cimento C, 32 (2). pp. 19-22. ISSN 1826-9885
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Abstract
In the framework of large-scale genotypic studies (describing the distribution of allele frequencies inside human genome) we characterize the Linkage Disequilibrium (LD) matrix as a network of relationships between alleles. We propose a suitable matrix discretization threshold, after a characterization of the distribution of noisy values inside LD matrix. We compare the main network parameters of a real LD matrix with two null models (Erdos-Renyi random network and a rewiring of the original network), in order to highlight the peculiar features of the LD network. We conclude stating the need of adequate computing tools for handling the high-dimensional data coming from Genome-Wide genotyping datasets.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Systems biology ; Genomics ; Genetic diseases |
| Subjects: | 500 Scienze naturali e Matematica > 530 Fisica |
| Depositing User: | Marina Spanti |
| Date Deposited: | 24 Mar 2020 17:07 |
| Last Modified: | 24 Mar 2020 17:07 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/16477 |
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