Non-Uremic Calciphylaxis: A Rare Diagnosis with Limited Therapeutic Strategies

Gomes, Felisbela Miguel and La Feria, Pedro and Costa, Catarina and Santos, Rita (2018) Non-Uremic Calciphylaxis: A Rare Diagnosis with Limited Therapeutic Strategies. European Journal of Case Reports in Internal Medicine, 5 (12). ISSN 2284-2594

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Calciphylaxis is a rare condition characterized by the emergence of non-healing skin ulcers secondary to arterial calcification and thrombosis, typically diagnosed in patients with end-stage kidney disease (ESKD). When it develops in patients without ESKD, it is called non-uremic calciphylaxis (NUC). The latter is an even rarer diagnosis with an uncertain pathophysiology and a high mortality rate (52%), mainly due to sepsis (50%). Cutaneous biopsy is diagnostic. Therapeutic measures recommended for NUC are limited to wound debridement, analgesia, and control of infection and risk factors. Other therapeutic options exist but with a low level of evidence. We present the case of a 78-year-old woman with NUC in her lower limbs who died of sepsis. NUC is a therapeutic challenge lacking efficient strategies.

Item Type: Article
Uncontrolled Keywords: Calciphylaxis, leg ulcer, vascular calcification, sepsis
Subjects: 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Greta Di Blasio
Date Deposited: 10 Jun 2019 16:17
Last Modified: 10 Jun 2019 16:17

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