Propofol-Induced Hepatitis

Raisi, Hanna and Longerich, Thomas and Moreira Assuncao, Bernardo and Mueller, Sebastian and Schirmacher, Peter and Seitz, Helmut-Karl (2020) Propofol-Induced Hepatitis. European Journal of Case Reports in Internal Medicine, 7 (12). pp. 1-3. ISSN ISSN: 2284-2594

[img]
Preview
Text
1921-Article Text-16947-1-10-20201005.pdf - Published Version

Download (515kB) | Preview
Official URL: https://www.ejcrim.com/index.php/EJCRIM/issue/view...

Abstract

Objectives: To present a rare case of propofol-induced hepatitis.Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy. Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition.Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.

Item Type: Article
Uncontrolled Keywords: Propofol, hepatitis, anaesthesia
Subjects: 600 Tecnologia - Scienze applicate
600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici)
600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale)
Depositing User: Marina Spanti
Date Deposited: 20 Dec 2021 14:32
Last Modified: 20 Dec 2021 14:32
URI: http://eprints.bice.rm.cnr.it/id/eprint/21126

Actions (login required)

View Item View Item