Raisi, Hanna and Longerich, Thomas and Moreira Assuncao, Bernardo and Mueller, Sebastian and Schirmacher, Peter and Seitz, Helmut-Karl (2020) Propofol-Induced Hepatitis. European Journal of Case Reports in Internal Medicine, 7 (12). pp. 1-3. ISSN ISSN: 2284-2594
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Abstract
Objectives: To present a rare case of propofol-induced hepatitis.Materials and methods: A 59-year old man was referred to our department because of suspicion of toxic hepatitis after propofol anaesthesia for endoscopic colonoscopy. Results: The patient had jaundice, increased transaminases demonstrating liver necrosis, and liver stiffness of 18 kPa. Liver biopsy revealed bridging necrosis and initial post-collapse fibrosis. Following therapy with steroids and N-acetyl cysteine, the patient was discharged on the seventh day after admission in good general condition.Conclusion: Although propofol is considered safe, it can cause acute hepatitis, the seventh published case of which is reported here. Importantly, treatment with N-acetyl cysteine, a radical scavenger, but especially with steroids resulted in hepatic improvement.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Propofol, hepatitis, anaesthesia |
| Subjects: | 600 Tecnologia - Scienze applicate 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) 600 Tecnologia - Scienze applicate > 610 Medicina e salute (Classificare qui la tecnologia dei servizi medici) > 616 Malattie (classificare qui la Clinica medica, la medicina basata sull'evidenza, la Medicina interna, la Medicina sperimentale) |
| Depositing User: | Marina Spanti |
| Date Deposited: | 20 Dec 2021 14:32 |
| Last Modified: | 20 Dec 2021 14:32 |
| URI: | http://eprints.bice.rm.cnr.it/id/eprint/21126 |
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